ABSTRACT Hyperthyroidism can induce elevation in several liver function tests including aminotransferases, alkaline phosphatases and, less frequently, serum bilirubin. These alterations are usually mild and asymptomatic. We report a 26 year-old male presenting with palpitations, progressive jaundice, choluria and generalized itching. Laboratory tests were compatible with hyperthyroidism and a mild elevation of bilirubin, alkaline phosphatases and gamma glutamyl transpeptidase. A liver biopsy showed portal hepatitis with canalicular cholestasis. The patient was treated temporarily with glucocorticoids, cholestyramine and betablockade. Thereafter, he was treated with radioactive iodine, after which serum bilirubin decreased steadily until normalization in ten weeks.

El hipertiroidismo puede producir elevación de aminotransferasas, fosfatasas alcalinas y, menos frecuentemente, de bilirrubina sérica. Habitualmente, estas alteraciones son leves y asintomáticas. Reportamos un hombre de 26 años con hipertiroidismo secundario a enfermedad de Basedow-Graves, que debutó con un cuadro colestásico, inicialmente estudiado por sospecha de patología hepática autoinmune que incluyó biopsia hepática. Posteriormente, se diagnosticó hipertiroidismo que fue tratado con glucocorticoides, colestiramina y beta bloqueo como puente a terapia definitiva con radioyodo. La evolución mostró disminución progresiva hasta la normalización de bilirrubina sérica.

ABSTRACT Objective Our objective was to evaluate the trend of antithyroglobulin antibodies (TgAb) during follow-up of patients with differentiated thyroid cancer (DTC) treated without RAI, as well as their role in the risk of recurrence. Subjects and methods This was a prospective, descriptive study. A total of 152 consecutive patients with DTC treated in a single institution undergoing total thyroidectomy without RAI and followed for a median of 2.3 years (0.5-10.3) were divided in two groups: TgAb(-) (n = 111) and TgAb(+) (n = 41). Patients were classified according to AJCC 7th and 8th editions, as well as to their risk of recurrence and response to treatment categories. Results Both groups, TgAb(-) and TgAb(+), were similar regarding patient and tumor characteristics. At the end of follow-up, 90 (59.2%), 57 (37.5%), 3 (2%) and 2 (1.3%) patients achieved excellent, indeterminate, biochemically incomplete and structurally incomplete response, respectively. The risk of structural recurrence was similar in both groups (TgAb[-] 0.9% vs. TgAb[+] 2.4%, p = 0.46). In the TgAb(+) group, TgAb became negative in 10 (24.4%), decreased ≥ 50% without negativization in 25 (60.9%), decreased < 50% in 4 (9.8%) and remained stable or increased in 2 (4.9%) cases. The only incomplete structural response had increasing TgAb during follow-up. Conclusions In properly selected patients with DTC, TgAb concentration immediately after total thyroidectomy should not mandate RAI ablation, and their trend during follow-up may impact the risk of recurrence.

ABSTRACT Objective We aimed to describe the presentation of papillary microcarcinoma (PTMC) and identify the clinical and histological features associated with persistence/recurrence in a Latin American cohort. Subjects and methods Retrospective study of PTMC patients who underwent total thyroidectomy, with or without radioactive iodine (RAI), and who were followed for at least 2 years. Risk of recurrence was estimated with ATA 2009 and 2015 classifications, and risk of mortality with 7th and 8th AJCC/TNM systems. Clinical data obtained during follow-up were used to detect structural and biochemical persistence/recurrence. Results We included 209 patients, predominantly female (90%), 44.5 ± 12.6 years old, 183 (88%) received RAI (90.4 ± 44.2 mCi), followed-up for a median of 4.4 years (range 2.0–7.8). The 7th and 8th AJCC/TNM system classified 89% and 95.2% of the patients as stage I, respectively. ATA 2009 and ATA 2015 classified 70.8% and 78.5% of the patients as low risk, respectively. Fifteen (7%) patients had persistence/recurrence during follow-up. In multivariate analysis, only lymph node metastasis was associated with persistence/recurrence (coefficient beta 4.0, p = 0.016; 95% CI 1.3-12.9). There were no PTMC related deaths. Conclusions Our series found no mortality and low rate of persistence/recurrence associated with PTMC. Lymph node metastasis was the only feature associated with recurrence in multivariate analysis. The updated ATA 2015 and 8th AJCC/TNM systems classified more PTMCs than previous classifications as low risk of recurrence and mortality, respectively.

Pinus patula Schiede ex Schltdl. et., Cham. is an endemic pine of México improved abroad because of its fast growth rate and should be evaluated to be reintroduced into the country. In this study the development of progenies with different breeding levels was compared in two trials in contrasting environments: Aquixtla, Puebla, at 2930 m (S1) and Acaxochitlán, Hidalgo, at 2260 m elevation (S2). Survival was evaluated at 6 years of age and at 5 and 6 years normal diameter (ND), total height (ALT), and stem volume (VOL) of 36 families improved in Colombia and South Africa (group M) and of 36 native families phenotypically selected (group S). At 6 years, survival was 72.7 % in S1 and 90 % in S2, with better growth in the latter site. There were significant differences (p≤ 0.05) between the two groups of families in all variables in both years. Progenies of the M group were higher in the volume of the trunk in S1 (4.3 vs. 3.6 dm³) but not in S2 (10.7 vs. 13.5 dm³). In S1, heritabilities (h i²) for growth traits ranged from 0.09 to 0.12 and in S2 from 0.26 to 0.35. Families of M Group had higher values of h i² in S1 but in S2 values were similar. Genetic (r g) and phenotypic (r p) correlations between the growth variables for S1 and S2 ranged from 0.80 to 1.0 (≥ 0.80) at both ages. The genotypeX environment interaction (GX A) was high because the values of rB in both ages were lower than 0.70 and 0.0 in some cases. The group of M families had lower GX A interaction in all variables evaluated.

Pinus patulaSchiede ex Schltdl. et Cham. es un pino endémico de México mejorado en el extranjero por ser de crecimiento rápido y debe evaluarse al ser reintroducido. En este estudio se comparó el desarrollo de progenies con diferentes niveles de mejora genética en dos ensayos en ambientes contrastantes: Aquixtla, Puebla, a 2930 m (S1) y Acaxochitlán, Hidalgo, a 2260 m de elevación (S2). A los 6 años de edad se evaluó la supervivencia y a los 5 y 6 años el diámetro normal (DN), la altura total (ALT) y el volumen del tronco (VOL) de 36 familias mejoradas en Colombia y Sudáfrica (grupo M) y de 36 nativas seleccionadas fenotípicamente (grupo S). A los 6 años, la supervivencia fue 72.7 % en S1 y 90 % en S2, con mejores crecimientos en este último sitio. Hubo diferencias significativas (p≤0.05) entre los dos grupos de familias en todas las variables evaluadas en ambos años. Las progenies del grupo M fueron superiores en el volumen del tronco en S1 (4.3 vs. 3.6 dm³) pero no en S2 (10.7 vs. 13.5 dm³). En S1, las heredabilidades (h i²) para las características de crecimiento variaron de 0.09 a 0.12 y en S2 de 0.26 a 0.35. Las familias del grupo M presentaron mayores valores de h i² en S1 pero en S2 los valores fueron similares. Las correlaciones genéticas (r g) y fenotípicas (r p) entre las variables de crecimiento para S1 y S2 variaron de 0.80 a 1.0 (≥0.80) en las dos edades. La interacción genotipo X ambiente (GXA) fue alta porque los valores de rB en ambas edades fueron menores a 0.70 y 0.0 en algunos casos. El grupo de familias M presentó menor interacción G X A en todas las variables evaluadas.

We describe a case of primary penis lymphoma in a 71yr old man. We review the bibliography and we emphasize the peculiarity and different sorts of clinical presentation. The initial symptoms were insidious. Physical examination and ultrasound findings made it indistinguishable from other tumors. A MRI confirmed the presence of a tumoral process with a homogeneous density in the distal part of the penis whose biopsy with immune histological processing confirme us the diagnosis of primary penis lymphoma. The combined treatment with chemotherapy and radiotherapy allowed preserving the sexual organ and being without disease at 48 month of follow up.

Se describe un caso de linfoma primario de pene en un paciente de 71 años. Se revisa la bibliografía destacando su extrema rareza y las diferentes formas clínicas de presentación. La clínica fue insidiosa, y los datos de la exploración física y los hallazgos ecográficos la hicieron indistinguible de otras neoplasias. La resonancia magnética confirmó la existencia de un proceso neoformativo de densidad homogénea en la parte distal del pene, cuya toma biópsica junto con las técnicas de inmunohistoquímica confirmó el diagnóstico de linfoma de pene. El tratamiento combinado de quimio y radioterapia permitió conservar el órgano, encontrándose el paciente a los 48 meses libre de enfermedad.

This paper presents an integrated analysis of data from calcareous nannofossils,foraminifera and geophysical logs from two exploratory wells in the Macuspana basin, southeastern Gulf of Mexico. This combination permits to propose a sequence stratigraphy frame-work for the studied-wells. Biostratigraphic resolution and reliability increase with the integration of results from both fossil groups. On well A, the following species are used: Helicosphaera kamptneri. Reticulofenestra pseudoumbilica. Minylitha convallis. Discoaster hamatus. Globorotalia obesa and Globorotalia mayeri. On well B, the useful species are: Calcidiscus macintyrei. Reticulofenestra pseudoumbilica. Discoaster quinqueramus and Globorotalia mayeri. In well A, three stratigraphic sequence candidates are recognizable, and they are correlatable with the third order eustatic cycles TB-2.6, TB-3.1 and TB-3.5?. In wellB, five stratigraphic sequence candidates are recognized, which are correlatable with the third order eustatic cycles TB-2.6, TB-3.1, TB-3.2, TB-3.3 and TB-3.6?. Results indicate that the studied sections were deposited from middle Miocene to Pleistocene. The biostratigraphic results, combined with sequence stratigraphy, will help to propose a sequence stratigraphy model.

Este trabajo presenta el análisis integrado de nanofósiles calcáreos, foraminíferos y registros geofísicos de dos pozos exploratorios en la cuenca Macuspana, sureste del Golfo de México. Esta combinación permite proponer un marco de secuencias estratigráficas para los pozos estudiados. La resolución bioestratigráfica y la confiabilidad de los resultados bioestratigráficos aumentan cuando se integran los resultados de estos dos grupos fósiles. En el pozo A se utilizan las especies Helicosphaera kamptneri, Retículofenestra pseudoumbilica, Minylitha convallis, Discoaster hamatus, Globorotalia obesa y Globorotalia mayeri. Mientras que en el pozo B las especies útiles son: Calcidiscus macintyrei, Retículo fenestra pseudoumbilica, Discoaster quinqueramus y Globorotalia mayeri. En la sucesión sedimentaria del pozo A se reconocen tres candidatos a secuencias estratigráficas, correlacionables con los ciclos de 3er orden: TB-2.6, TB-3.1 y TB-3.5?. Para el pozo B se reconocen cinco candidatos a secuencias estratigráficas, correlacionables con los ciclos de 3er orden: TB-2.6, TB-3.1, TB-3.2, TB-3.3 y TB-3.6?. De acuerdo con los resultados, los sedimentos fueron depositados desde el Mioceno medio hasta el Pleistoceno. Los resultados bioestratigráficos y su relación con la estratigrafía de secuencias permitirán auxiliar en la integración de datos micropaleontológicos para proponer un modelo estratigráfico.

Several hydrous layered silicates, modified kanemites, aluminosilicates and various mesoporous materials, were hydrothermally synthesized, and then evaluated as new catalysts for obtaining benzyltoluenes. In addition, the dependence of the catalyst concentration, the influence of the reaction time and the effect of the temperature were studied.

Varios materiales mesoporosos como los silicatos laminares hidratados y kanemitas modificadas fueron obtenidos hidrotérmicamente y posteriormente evaluados como nuevos catalizadores en la obtención de benciltoluenos. Asimismo, se estudia la dependencia de la concentración del catalizador, la influencia del tiempo de reacción y el efecto de la temperatura.